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Heart disease and testosterone are mighty complex on their own, and studies that evaluate the two together are more complex still. In a few instances, when one hormone goes up, the other goes down. (This is especially true of testosterone levels in certain men who develop a condition called benign prostatic hyperplasia -- in which their body makes too much testosterone.) That may explain why, in studies of both testosterone therapy and testosterone replacement therapy, there is a significant rise in the total testosterone in men who have been taking testosterone but are now taking a testosterone-replacement medication:In 2010, in a review of the literature on erectile disorders in men, Dr. Mark J. Krawitz, an endocrinologist at the University of North Carolina School of Medicine, explained why the rise in testosterone in the past decade and a half might have something to do with these drugs:For men who have a very high total testosterone level, the increase is primarily due to a modest rise in the testosterone concentration in the blood. In patients with the opposite condition, however, the increase is primarily due to a rise in their levels of free testosterone, which, due to the higher levels of the two steroids, tends to stay relatively constant. These patients need to be monitored closely while they are taking these drugs to determine whether they have a potential problem that might make total testosterone levels very high.But studies also show that testosterone levels in men who are on testosterone replacement therapy aren't necessarily going up -- they might be dropping a bit, due to a lack of absorption. That's because when men get testosterone in the morning, it goes to the liver, the same place in the body that doesn't typically give it out in response to hormones like sex hormones. Because testosterone is a fat-soluble steroid, when testosterone enters the liver, it can end up with a lower concentration of its active metabolite, dihydrotestosterone, which then goes to the testes -- to be taken by the penis as an alternative form of male birth control.But if testosterone therapy is a safe and effective alternative to other male forms of birth control -- whether the pills themselves provide any pleasure or aren't as addictive or dangerous as other forms of birth control -- the potential for a drop in total testosterone for people who take testosterone replacement therapy is far more likely to have an impact on their health than a drop in total testosterone for men getting birth control from somewhere else.Similar articles: